Biochemistry (Lippincott Illustrated Reviews Series) Sixth, North American Edition

Book Preface

Proteins are the most abundant and functionally diverse molecules in living systems. Virtually every life process depends on this class of macromolecules. For example, enzymes and polypeptide hormones direct and regulate metabolism in the body, whereas contractile proteins in muscle permit movement. In bone, the protein collagen forms a framework for the deposition of calcium phosphate crystals, acting like the steel cables in reinforced concrete. In the bloodstream, proteins, such as hemoglobin and plasma albumin, shuttle molecules essential to life, whereas immunoglobulins fight infectious bacteria and viruses. In short, proteins display an incredible diversity of functions, yet all share the common structural feature of being linear polymers of amino acids. This chapter describes the properties of amino acids. Chapter 2 explores how these simple building blocks are joined to form proteins that have unique three-dimensional structures, making them capable of performing specific biologic functions.

Contents
UNIT I: Protein Structure and Function
Chapter 1: Amino Acids
Chapter 2: Structure of Proteins
Chapter 3: Globular Proteins
Chapter 4: Fibrous Proteins
Chapter 5: Enzymes
UNIT II: Bioenergetics and Carbohydrate Metabolism
Chapter 6: Bioenergetics and Oxidative Phosphorylation
Chapter 7: Introduction to Carbohydrates
Chapter 8: Introduction to Metabolism and Glycolysis
Chapter 9: Tricarboxylic Acid Cycle and Pyruvate Dehydrogenase
Complex
Chapter 10: Gluconeogenesis
Chapter 11: Glycogen Metabolism
Chapter 12: Metabolism of Monosaccharides and Disaccharides
Chapter 13: Pentose Phosphate Pathway and Nicotinamide Adenine
Dinucleotide Phosphate
Chapter 14: Glycosaminoglycans, Proteoglycans, and Glycoproteins
UNIT III: Lipid Metabolism
Chapter 15: Dietary Lipids Metabolism
Chapter 16: Fatty Acid, Ketone Body, and Triacylglycerol Metabolism
Chapter 17: Phospholipid, Glycosphingolipid, and Eicosanoid
Metabolism
Chapter 18: Cholesterol, Lipoprotein, and Steroid Metabolism
UNIT IV: Nitrogen Metabolism
Chapter 19: Amino Acids: Disposal of Nitrogen
Chapter 20: Amino Acid Degradation and Synthesis
Chapter 21: Conversion of Amino Acids to Specialized Products
Chapter 22: Nucleotide Metabolism
UNIT V: Integration of Metabolism
Chapter 23: Metabolic Effects of Insulin and Glucagon
Chapter 24: The Feed–Fast Cycle
Chapter 25: Diabetes Mellitus
Chapter 26: Obesity
Chapter 27: Nutrition
Chapter 28: Vitamins
UNIT VI: Storage and Expression of Genetic Information
Chapter 29: DNA Structure, Replication, and Repair
Chapter 30: RNA Structure, Synthesis, and Processing
Chapter 31: Protein Synthesis
Chapter 32: Regulation of Gene Expression
Chapter 33: Biotechnology and Human Disease
Appendix: Clinical Cases
Index