Steroids: From Physiology to Clinical Medicine
Understanding complex mechanisms of action and key roles in different biological processes in the body has moved steroid science and medicine to expand rapidly in the past decades. Dozens of distinct steroids are identified as both control and target molecules, with regulation of physiological and pathophysiological steroidogenesis recognized as one of the essential research topics in the field. On the other hand, steroids have been practiced as both medical agents and clinical markers for many purposes, from bone marrow stimulation to growth monitoring. This book covers contemporary basic science on steroid research, along with steroid practical application in endocrinology and clinical medicine.
The book is divided in two parts. The first part deals with physiological and pathophysiological roles of steroids, with reference to production and action of gonadal steroids, role of steroid sulfonation in mammalian growth and development, sex specific and steroids-dependent mechanism of hippocampal function, and the importance of hydroxysteroid dehydrogenases for the modulation of tissue glucocorticoid availability. The second part will cover different aspects of steroids application in clinical environment. Topics covered in the second part include the endocrine function after ovarian transplantation in terms of sex steroid production from the cryopreserved and reimplanted ovaries, the diagnostic significance of collection, storage and measurement of androgens in saliva of females, main drawbacks of steroids use in sport and exercise, analysis of serum steroid hormone profiles in patients with adrenocortical tumors, and correlation between salivary and serum cortisol responses after alcohol intake.
In response to the need to address novel and valuable information on steroids science and medicine, we sincerely hope that this book will enable readers to comprehend this fastgrowing and exciting scientific field.
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|May 30, 2020|
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