Essential Genetics and Genomics 7th Edition

Book Preface

A good teacher aims to uncover a subject, not cover it. So said a wise former teacher of mine. In revising Essential Genetics and Genomics, Seventh Edition, I’ve tried to heed this advice. To uncover a subject means to expose, exhibit, unveil. To help uncover genetics, this new edition is:

â– â–  Streamlined, with emphasis on concepts illuminated by vivid example and stripped of extraneous detail
â– â–  Focused, with Learning Objectives stated explicitly at the beginning of each chapter
â– â–  Skills oriented, with Stop & Think problems inserted at strategic points in the text to enhance the reading experience and encourage higherorder, analytical thinking.
The brevity of the text meets the needs of the shorter, less comprehensive introductory course of one semester or quarter. The choice of topics is intended to help students master the following scientific competencies:
â– â–  Understand the basic processes of gene transmission, mutation, expression, and regulation.
â– â–  Analyze genetic processes using numerical relationships including ratios and proportions.
â– â–  Learn to formulate genetic hypotheses in a statistical framework, work out their consequences, and test the results against observed data.
â– â–  Develop basic skills in problem solving, including single-concept exercises, those requiring the application of several concepts in logical order, and numerical problems requiring some arithmetic for solution.
â– â–  Interpret genetic data and make valid inferences to reveal the underlying causes.
â– â–  Acquire an appreciation of current trends in genetics, as well as the social and historical context in which genetics has developed. Scientific competency is the desired learning outcome of any course in a curriculum in STEM (science, technology, engineering, mathematics). Genetics is an excellent subject for achieving scientific competency. It is integrative over a broad territory, ranging from molecular biology to evolutionary genetics. It is alsoquantitative, using concepts from probability, statistics, and computational biology. Fortunately, students come to a course in genetics highly motivated because of media reports about the human genome and genetic risk factors for disease, as well as many social and ethical controversies related to genetics such as direct-to-consumer and over-the-counter genetic testing, genetic privacy, cloning, stem-cell research, and genetically modified organisms. The challenges for the instructor are to sustain this motivation and to help students acquire the skills and ha

Brief Contents
Chapter 1 The Genetic Code of Genes and Genomes 1
Chapter 2 Transmission Genetics: Heritage from Mendel 33
Chapter 3 The Chromosomal Basis of Heredity 69
Chapter 4 Gene Linkage and Genetic Mapping 109
Chapter 5 Human Chromosomes and Chromosome Behavior 147
Chapter 6 DNA Structure, Replication, and Manipulation 185
Chapter 7 The Genetics of Bacteria and Their Viruses 215
Chapter 8 The Molecular Genetics of Gene Expression 247
Chapter 9 Molecular Mechanisms of Gene Regulation 281
Chapter 10 Genomics, Proteomics, and Genetic Engineering 317
Chapter 11 The Genetic Control of Development 353
Chapter 12 Molecular Mechanisms of Mutation and DNA Repair 381
Chapter 13 Molecular Genetics of the Cell Cycle and Cancer 416
Chapter 14 Molecular Evolution and Population Genetics 443
Chapter 15 The Genetic Basis of Complex Traits 477