CURRENT Medical Diagnosis and Treatment 2021 60th Edition

Book Preface

Current Medical Diagnosis & Treatment 2021 (CMDT 2021) is the 60th edition of this single-source reference for  practitioners in both hospital and ambulatory settings. The book emphasizes the practical features of clinical diagnosis and  patient management in all fields of internal medicine and in specialties of interest to primary care practitioners and to  subspecialists who provide general care.
Our students have inspired us to look at issues of race and justice, which surely impact people’s health. We have therefore  reviewed the content of our work to ensure that it contains the dignity and equality that every patient deserves.

INTENDED AUDIENCE FOR CMDT

House officers, medical students, and all other health professions students will find the descriptions of diagnostic and  therapeutic modalities, with citations to the current literature, of everyday usefulness in patient care. Internists, family physicians, hospitalists, nurse practitioners, physician assistants, and all primary care providers will  appreciate CMDT as a ready reference and refresher text. Physicians in other specialties, pharmacists, and dentists will find  the book a useful basic medical reference text. Nurses, nurse practitioners, and physician assistants will welcome the format  and scope of the book as a means of quickly referencing medical diagnosis and treatment modalities. Patients and their family members who seek information about the nature of specific diseases and their diagnosis and  treatment may also find this book to be a valuable resource.

NEW IN THIS EDITION OF CMDT
• INNOVATIVE TABLE

highlighting the “Year in Review: Key Clinical Updates in CMDT 2021,” individually listed with  page numbers and reference citations, for easy access to significant changes in this edition
• New section on SARS-CoV-2 virus and COVID-19 infection
• Extensive revision of the Viral & Rickettsial Infections chapter, including new section on acute flaccid myelitis as well  as updates on measles, mumps, and Zika virus
• 140 NEW online images in the Heart Disease, Gastrointestinal Disorders, and Cancer chapters
• Addition of the 2019 European guidelines for treating pulmonary embolism
• New table outlining agents to consider for reversing anticoagulant effect during life-threatening bleeding based on the  Anticoagulation Forum and American Society of Hematology 2019 guidelines
• Bedaquiline considered first-line medication for multidrug-resistant tuberculosis
• Lefamulin, a new commercially available medication for treating community-acquired bacterial pneumonia
• New information on the combination of emtricitabine/tenofovir alafenamide as antiretroviral treatment for preexposure  prophylaxis among men
• A two-drug regimen, dolutegravir plus lamivudine, included in the top recommended HIV antiretroviral regimens
• Recommendation from the Advisory Committee on Immunization Practices for shared clinical decision-making  regarding HPV vaccination for adults aged 26–45 years
• Substantial revision of the Sexual & Gender Minority Health chapter
• Bempedoic acid, a new FDA-approved pharmacologic option for lowering LDL cholesterol in patients who cannot tolerate statins
• FDA approval of various closed loop systems that adjust basal insulin delivery for diabetic patients
• Eculizumab, a newly FDA-approved medication for both myasthenia gravis and neuromyelitis optica
• FDA approval of lasmiditan, a new pharmacologic option that can safely be given to migraine sufferers with cardiovascular risk factors
• The sodium-glucose linked transporter (SGLT) inhibitors slow progression of early diabetic nephropathy in addition to  their having cardioprotective effects
• The US Preventive Services Task Force recommendation for hepatitis C screening of asymptomatic adults between ages
18 and 79 years
• FDA approval of adjuvant trastuzumab emtansine for patients with HER2-positive breast cancer with residual disease  after standard trastuzumab-containing neoadjuvant therapy
• Data from HER2CLIMB, a phase III trial, expected to lead to FDA approval of a new therapy for breast cancer patients  with pretreated HER2-positive advanced disease
• Promising results from phase 3 clinical trials of gene therapy for hemophilia A and B
• Information on bremelanotide, a second FDA-approved medication for hypoactive sexual desire disorder in premenopausal women
• Mepolizumab, newly FDA approved for the treatment of eosinophilic granulomatosis with polyangiitis

OUTSTANDING FEATURES OF CMDT
• Medical advances up to time of annual publication
• Detailed presentation of internal medicine disciplines, plus primary care topics in gynecology, obstetrics, dermatology,  ophthalmology, otolaryngology, psychiatry, neurology, toxicology, urology, geriatrics, orthopedics, women’s health,  sexual and gender minority health, preventive medicine, and palliative care
• Concise format, facilitating efficient use in any practice setting
• More than 1000 diseases and disorders
• Annual update on HIV/AIDS and other newly emerging infections
• Specific disease prevention information
• Easy access to medication dosages, with trade names indexed and costs updated in each edition
• Recent references, with unique identifiers (PubMed, PMID numbers) for rapid downloading of article abstracts and, in  some instances, full-text reference articles

E-CHAPTERS, CMDT ONLINE, & AVAILABLE APPS
Seven e-chapters listed in the Table of Contents can be accessed at www.AccessMedicine.com/CMDT. These online-only  chapters (available without need for subscription) include
• Anti-Infective Chemotherapeutic & Antibiotic Agents
• Diagnostic Testing & Medical Decision Making
• Information Technology in Patient Care
• Integrative Medicine
• Podiatric Disorders
• Women’s Health Issues
• Appendix: Therapeutic Drug Monitoring, Laboratory Reference Intervals, & Pharmacogenetic Tests
Institutional or individual subscriptions to AccessMedicine also have full electronic access to CMDT 2021. Subscribers to CMDT Online receive full electronic access to CMDT 2021 as well as
• An expanded, dedicated media gallery
• Quick Medical Diagnosis & Treatment (QMDT)—a concise, bulleted version of CMDT 2021
• Guide to Diagnostic Tests—for quick reference to the selection and interpretation of commonly used diagnostic tests
• CURRENT Practice Guidelines in Primary Care—delivering concise summaries of the most relevant guidelines in  primary care
• Diagnosaurus—consisting of 1000+ differential diagnoses