Biochemistry 9th Edition

Book Preface

This text is intended for students in any eld of science or engineering who want a one-semester introduction to biochemistry but who do not intend to be biochemistry majors. Our main goal in writing this book is to make biochemistry as clear and applied as possible and to familiarize science students with the major aspects of biochemistry. For students of biology, chemistry, physics, geology, nutrition, sports physiology, and agriculture, biochemistry impacts greatly on the content of their elds, especially in the areas of medicine and biotechnology.

For engineers, studying biochemistry is especially important for those who hope to enter a career in biomedical engineering or some form of biotechnology. Students who will use this text are at an intermediate level in their studies. A beginning biology course, general chemistry, and at least one semester of organic chemistry are assumed as preparation.

What’s New

All textbooks evolve to meet the interests and needs of students and instructors and to include the most current information. Several changes mark this edition. Biochemistry Hot Topics These articles are now conveniently located within the relevant chapters. They highlight new breakthroughs and topics in the area of biochemistry such as CRISPR, Alzheimer’s disease, epigenetics, brown fat, andmore! Updated Coverage Each chapter in the text has been updated with the current developments and scientic ndings in the biochemistry eld.

New Design and Updated Art Illustrations throughout the text have been redrawn for improved consistency. In conjunction with the book’s updatedart program, a more contemporary design and color palette have been utilized. Further Reading An annotated bibliography is now provided in the Further Reading section at the end of each chapter, making these resources more easily accessible to the student.

Table of Changes by Chapter

Chapter 1 Added summary of major types of biomolecules
Chapter 3 Expanded Biochemical Connection on oxytocin and its social effects, added four new Review Exercises
Chapter 4 Updated Biochemical Connection on prion diseases, added Hot Topic about aging
Chapter 6 Updated Biochemical Connection on enzyme markers for diseases
Chapter 7 Added new Hot Topic on Alzheimer’s disease, added four new Review Exercises
Chapter 8 Added expanded Hot Topic on happiness and depression, added two new Review Exercises
Chapter 9 Added Hot Topic on breast cancer, added material on long noncoding RNA, added new section on medical applications of RNA, deleted Biochemical Connection on synthetic genome
Chapter 10 Added brief mention of replication termination
Chapter 11 Added new Hot Topic on epigenetics, deleted Biochemical Connections box about CREB, deleted Biochemical Connections about epigenetics and cancer
Chapter 13 Added new Hot Topic on clustered, regularly interspaced, short palindromic repeat technology in combination with the Cas9 RNA-guided nuclease (CRISPR/Cas9) method of genetic engineering, example of CRISPR/Cas9 to engineer Innate potato
Chapter 14 Updated content on vaccine development for
Ebola and advances in stem cell research
Chapter 16 New research findings that correlate the use of artificial sweeteners to gut microbiome, suggesting the reason diet products may not result in weight loss
Chapter 17 Updated content associated with biofuels
Chapter 19 New information on the use of the compound 1080 (sodium fluoroacetate) for control of mammal populations in New Zealand
Chapter 20 Added a new Hot Topic on brown fat to include recent research developments demonstrating the benefits of brown adipose tissue to maintenance of healthy metabolism
Chapter 24 Added updated Hot Topic on G-protein– coupled receptors to include recent research on the biased agonism or functional selectivity model associated with opioid receptors